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Nadir testosterone within first year of androgen-deprivation therapy (ADT) predicts for time to castration-resistant progression: A secondary analysis of the PR-7 trial of intermittent versus continuous ADT

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Klotz L., O’Callaghan C., Ding K., Toren P., Dearnaley D., Higano C.S., Horwitz E., Malone S., Goldenberg L., Gospodarowicz M., Crook J.M.

Journal of Clinical Oncology 2015 33:10 (1151-1156)

Purpose Three small retrospective studies have suggested that patients undergoing continuous androgen deprivation (CAD) have superior survival and time to progression if lower castrate levels of testosterone ( < 0.7 nmol/L) are achieved. Evidence from prospective large studies has been lacking. Patients and Methods The PR-7 study randomly assigned patients experiencing biochemical failure after radiation therapy or surgery plus radiation therapy to CAD or intermittent androgen deprivation. The relationship between testosterone levels in the first year and cause-specific survival (CSS) and time to androgen-independent progression in men in the CAD arm was evaluated using Cox regression. Results There was a significant difference in CSS (P = .015) and time to hormone resistance (P = .02)among those who had first-year minimum nadir testosterone ? 0.7, > 0.7 to…(vermás)

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