Comprehensive Characterization of the Perioperative Morbidity of Cytoreductive Nephrectomy

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Gershman B., Moreira D.M., Boorjian S.A., Lohse C.M., Cheville J.C., Costello B.A., Leibovich B.C., Thompson R.H.

European Urology 2015

Background: Although cytoreductive nephrectomy (CN) has been associated with perioperative morbidity, data are lacking regarding the risk of prolonged length of stay (pLOS) and delay to receipt of systemic therapy (ST). Objective: To evaluate the association of clinicopathologic features with postoperative complications, pLOS, and time to receipt of ST. Design, setting, and participants: We evaluated 294 patients with M1 renal cell carcinoma treated between 1990 and 2009. Interventions: CN. Outcome measurements and statistical analysis: Logistic and Cox regressions were used to evaluate associations of clinicopathologic features with 30-d postoperative complications, pLOS (LOS ?75th percentile), and time to receipt of ST. Results and limitations: Fifteen (5%) patients experienced at least one Clavien grade ?3 early complication. Among patients for whom postsurgical ST was recommended, 61% did not receive ST within 60 d, but the delay was…(vermás)


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