Improving selection criteria for early cystectomy in high-grade T1 bladder cancer: A meta-analysis of 15,215 patients

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Martin-Doyle W., Leow J.J., Orsola A., Chang S.L., Bellmunt J.

Journal of Clinical Oncology 2015 33:6 (643-650)

Purpose: High-grade T1 (HGT1) bladder cancer is the highest risk subtype of non-muscle-invasive bladder cancer, with highly variable prognosis, poorly understood risk factors, and considerable debate about the role of early cystectomy. We aimed to address these questions through a meta-analysis of outcomes and prognostic factors. Methods: PubMed, EMBASE, Cochrane Central Register of Controlled Trials, and American Society of Clinical Oncology abstracts were searched for cohort studies in HGT1. We pooled data on recurrence, progression, and cancer-specific survival from 73 studies. Results: Five-year rates of recurrence, progression, and cancer-specific survival were 42% (95% CI, 39% to 45%), 21% (95% CI, 18% to 23%), and…(ver más)


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