Five-year Analysis of a Multi-institutional Prospective Clinical Trial of Delayed Intervention and Surveillance for Small Renal Masses: The DISSRM Registry

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Pierorazio P.M., Johnson M.H., Ball M.W., Gorin M.A., Trock B.J., Chang P., Wagner A.A., McKiernan J.M., Allaf M.E.

European Urology 2015

Background: A growing body of retrospective literature is emerging regarding active surveillance (AS) for patients with small renal masses (SRMs). There are limited prospective data evaluating the effectiveness of AS compared to primary intervention (PI). Objective: To determine the characteristics and clinical outcomes of patients who chose AS for management of their SRM. Design, setting, and participants: From 2009 to 2014, the multi-institutional Delayed Intervention and Surveillance for Small Renal Masses (DISSRM) registry prospectively enrolled 497 patients with solid renal masses ?4.0. cm who chose PI or AS. Intervention: AS versus PI. Outcome measurements and statistical analysis: The registry was designed and powered as a noninferiority study based on historic recurrence rates for PI. Analyses were performed in an intention-to-treat manner. Primary outcomes were overall survival (OS) and cancer-specific survival (CSS). Results and limitations: Of the 497 patients enrolled, 274 (55%) chose PI and…(vermás)

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