International variations and trends in renal cell carcinoma incidence and mortality

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Znaor A., Lortet-Tieulent J., Laversanne M., Jemal A., Bray F.

European Urology 2015 67:3 (519-530)

Context Renal cell carcinoma (RCC) incidence rates are higher in developed countries, where up to half of the cases are discovered incidentally. Declining mortality trends have been reported in highly developed countries since the 1990s. Objective To compare and interpret geographic variations and trends in the incidence and mortality of RCC worldwide in the context of controlling the future disease burden. Evidence acquisition We used data from GLOBOCAN, the Cancer Incidence in Five Continents series, and the World Health Organisation mortality database to compare incidence and mortality rates in more than 40 countries worldwide. We analysed incidence and mortality trends in the last 10 yr using joinpoint analyses of the age-standardised rates (ASRs). Evidence synthesis RCC incidence in men varied in ASRs (World standard population) from approximately 1/100 000 in African countries to >15/100 000 in several Northern and Eastern European countries and among US blacks. Similar patterns were observed for women, although incidence rates…(vermás)


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