A novel urine cytology stain for the detection and monitoring of bladder cancer

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Davis N., Mor Y., Idelevich P., Terkieltaub D., Ziv V., Elkeles A., Lew S., Okon E., Laufer M., Ramon J., Kedar D., Baniel J., Yossepowitch O.

Journal of Urology 2014 

Purpose: CellDetect® is a unique platform technology comprising a proprietary plant extract and 3 dyes that enables color discrimination between malignant (red) and benign (green) cells based on specific metabolic alterations exclusive to the former. Preclinical studies and clinical trials demonstrated the applicability of the new technology in many cell culture lines and various cancers. We explored its performance characteristics in bladder cancer. Materials and Methods: We performed an open label, 2-step study at tertiary medical centers. The study enrolled patients with newly diagnosed or a history of urothelial carcinoma. Step 1 involved staining archived biopsies. Slides were evaluated by 2 independent pathologists, who determined the concordance of the new staining technology with the hematoxylin and eosin based diagnosis…(ver más)

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