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The role of radical prostatectomy and lymph node dissection in lymph node-positive prostate cancer: A systematic review of the literature

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Gakis G., Boorjian S.A., Briganti A., Joniau S., Karazanashvili G., Karnes R.J., Mattei A., Shariat S.F., Stenzl A., Wirth M., Stief C.G.

European Urology 2014 66:2 (191-199)

Context Because pelvic lymph node (LN)-positive prostate cancer (PCa) is generally considered a regionally metastatic disease, surgery needs to be better defined. Objective To review the impact of radical prostatectomy (RP) and pelvic lymph node dissection (PLND), possibly in conjunction with a multimodal approach using local radiotherapy and/or androgen-deprivation therapy (ADT), in LN-positive PCa. Evidence acquisition A systematic Medline search for studies reporting on treatment regimens and outcomes in patients with LN-positive PCa undergoing RP between 1993 and 2012 was performed. Evidence synthesis RP can improve progression-free and overall survival in LN-positive PCa, although there is a lack of high-level evidence…(ver más)

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