Yu O., Eberg M., Benayoun S., Aprikian A., Batist G., Suissa S., Azoulay L.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2014 32:1 (5-11)
To determine whether the use of statins after prostate cancer diagnosis is associated with a decreased risk of cancer-related mortality and all-cause mortality and to assess whether this association is modified by prediagnostic use of statins. A cohort of 11,772 men newly diagnosed with nonmetastatic prostate cancer between April 1, 1998, and December 31, 2009, followed until October 1, 2012, was identified using a large population-based electronic database from the United Kingdom. Time-dependent Cox proportional hazards models were used to estimate adjusted hazard ratios (HRs) with 95% CIs of mortality outcomes associated with postdiagnostic use of statins, lagged by 1 year to account for latency considerations and to minimize reverse causality, and considering e ffect modification by prediagnostic use of statins… (ver más)