Defining Progression in Nonmuscle Invasive Bladder Cancer: It is Time for a New, Standard Definition

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Lamm D., Persad R., Brausi M., Buckley R., Witjes J.A., Palou J., Böhle A., Kamat A.M., Colombel M., Soloway M.

Journal of Urology 2014 191:1 (20-27)

Purpose Despite being one of the most important clinical outcomes in nonmuscle invasive bladder cancer, there is currently no standard definition of disease progression. Major clinical trials and meta-analyses have used varying definitions or have failed to define this end point altogether. A standard definition of nonmuscle invasive bladder cancer progression as determined by reproducible and reliable procedures is needed. We examine current definitions of nonmuscle invasive bladder cancer progression, and propose a new definition that will be more clinically useful in determining patient prognosis and comparing treatment options. Materials and Methods The IBCG (International Bladder Cancer Group) analyzed published clinical trials and meta-analyses that examined nonmuscle invasive bladder cancer progression as of December 2012. The limitations of the definitions of progression used in these trials were considered, as were additional parameters associated with the advancement of nonmuscle invasive bladder cancer. Results The most commonly used definition of nonmuscle invasive bladder cancer progression is…(vermás)


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