Salvage lymph node dissection for nodal recurrence of prostate cancer after radical prostatectomy

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Tilki D., Mandel P., Seeliger F., Kretschmer A., Karl A., Ergün S., Seitz M., Stief C.G.

Journal of Urology 2015 193:2 (484-490)

Purpose We analyzed the impact of salvage lymph node dissection on the prognosis in patients with biochemical recurrence and positive lymph nodes on positron emission tomography/computerized tomography after radical prostatectomy. Materials and Methods We retrospectively analyzed the records of 58 patients who underwent pelvic and/or retroperitoneal salvage lymph node dissection from June 2005 to February 2012. Biochemical response was defined as prostate specific antigen less than 0.2 ng/ml 40 days after salvage treatment. Biochemical recurrence in those with a biochemical response was defined as prostate specific antigen greater than 0.2 ng/ml and increasing. Kaplan-Meier curves were used to assess time to biochemical recurrence, clinical recurrence and cancer specific survival. Cox and binary logistic regressions were used to determine factors influencing clinical recurrence and biochemical response. Results Median followup after salvage lymph node dissection was 39 months. A total of 13 patients (22.4%)…(vermás)

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