Human Papillomavirus Prevalence in Invasive Penile Cancer and Association with Clinical Outcome

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Djajadiningrat R.S., Jordanova E.S., Kroon B.K., van Werkhoven E., de Jong J., Pronk D.T.M., Snijders P.J.F., Horenblas S., Heideman D.A.M.

Journal of Urology 2014

Purpose: The incidence of penile cancer is increasing, and is suggested to be explained by changes in sexual practice and increased exposure of men to sexually transmitted high risk human papillomavirus infection. In penile cancers from a Dutch population treated in 1963 to 2001 we found a high risk human papillomavirus prevalence of about 30%. In this study we assessed the prevalence of high risk human papillomavirus-DNA in a more recent, contemporary penile cancer cohort and its association with patient survival. Materials and Methods: High risk human papillomavirus-DNA presence was assessed by GP5+6+ polymerase chain reaction in 212 formalin fixed, paraffin embedded invasive penile tumor specimens of patients treated between 2001 and 2009. The 5-year disease specific survival was calculated using the Kaplan-Meier method with the log rank test and Cox regression. Results: High risk human papillomavirus-DNA was detected in…(vermás)


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