Focal Therapy: Patients, Interventions, and Outcomes-A Report from a Consensus Meeting

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Donaldson I.A., Alonzi R., Barratt D., Barret E., Berge V., Bott S., Bottomley D., Eggener S., Ehdaie B., Emberton M., Hindley R., Leslie T., Miners A., McCartan N., Moore C.M., Pinto P., Polascik T.J., Simmons L., van der Meulen J., Villers A., Willis S., Ahmed H.U.

European Urology 2014

Background: Focal therapy as a treatment option for localized prostate cancer (PCa) is an increasingly popular and rapidly evolving field. Objective: To gather expert opinion on patient selection, interventions, and meaningful outcome measures for focal therapy in clinical practice and trial design. Design, setting, and participants: Fifteen experts in focal therapy followed a modified two-stage RAND/University of California, Los Angeles (UCLA) Appropriateness Methodology process. All participants independently scored 246 statements prior to rescoring at a face-to-face meeting. The meeting occurred in June 2013 at the Royal Society of Medicine, London, supported by the Wellcome Trust and the UK Department of Health. Outcome measurements and statistical analysis: Agreement, disagreement, or uncertainty were calculated as the median panel score. Consensus was derived from the interpercentile range adjusted for symmetry level. Results and limitations: Of 246 statements, 154 (63%) reached consensus. Items of agreement included the following: patients with intermediate risk and patients with unifocal and multifocal PCa are eligible…(ver más)


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