A nationwide cohort study of stage i seminoma patients followed on a surveillance program

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Mortensen M.S., Lauritsen J., Gundgaard M.G., Agerbæk M., Holm N.V., Christensen I.J., Von Der Maase H., Daugaard G.

European Urology 2014 66:6 (1172-1178)

Background Increasing concerns about late effects after adjuvant treatment for stage I seminoma have made surveillance an attractive alternative. Design, setting, and participants A retrospective, population-based study of Danish patients diagnosed with stage I seminoma between 1984 and 2008 and followed for 5 yr (n = 1954). Patient data were linked with national registries on November 30, 2012, to obtain information on late relapse, vital status, and cause of death. Outcome measurements and statistical analysis Disease-specific survival (DSS), overall survival, relapse rates, time to relapse, detection of relapse, and prognostic factors for relapse were described for the cohort. The Kaplan-Meier method was used to determine survival probabilities. A Cox proportional hazards model was used for multivariate analysis of prognostic factors. Results and limitations Median follow-up time was 15.1 yr…(ver más)

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