ERG protein expression in diagnostic specimens is associated with increased risk of progression during active surveillance for prostate cancer

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Berg K.D., Vainer B., Thomsen F.B., Røder M.A., Gerds T.A., Toft B.G., Brasso K., Iversen P.

European Urology 2014 66:5 (851-860)

Design, setting, and participants: This study included 265 patients followed on AS with prostate-specific antigen (PSA) measurements, clinical examinations, and 10-12 core rebiopsies from 2002 to 2012 in a prospectively maintained database. ERG immunohistochemical staining was performed on diagnostic paraffin-embedded formalin-fixed sections with a ready-to-use kit (anti-ERG, EPR3864). Men were characterised as ERG positive if a minimum of one tumour focus demonstrated ERG expression.Results and limitations: A total of 121 of 142 ERG-negative and 96 of 123 ERG-positive patients had complete diagnostic information. In competing risk models, the ERG-positive group showed significantly higher incidences of overall AS progression ( p < 0.0001) and of the subgroups PSA progression ( p < 0.0001) and histopathologic progression ( p < 0.0001)…(ver más)

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