Critical analysis of bladder sparing with trimodal therapy in muscle-invasive bladder cancer: A systematic review

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Ploussard G., Daneshmand S., Efstathiou J.A., Herr H.W., James N.D., Rödel C.M., Shariat S.F., Shipley W.U., Sternberg C.N., Thalmann G.N., Kassouf W.

European Urology 2014 66:1 (120-137)

Context Aims of bladder preservation in muscle-invasive bladder cancer (MIBC) are to offer a quality-of-life advantage and avoid potential morbidity or mortality of radical cystectomy (RC) without compromising oncologic outcomes. Because of the lack of a completed randomised controlled trial, oncologic equivalence of bladder preservation modality treatments compared with RC remains unknown. Objective This systematic review sought to assess the modern bladder-preservation treatment modalities, focusing on trimodal therapy (TMT) in MIBC. Evidence acquisition A systematic literature search in the PubMed and Cochrane databases was performed from 1980 to July 2013. Evidence synthesis Optimal bladder-preservation treatment includes a safe transurethral resection of the bladder tumour as complete as possible followed by radiation therapy (RT) with concurrentradiosensitising chemotherapy…(vermás)


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