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The relationship between characteristics of inguinal lymph nodes and pelvic lymph node involvement in penile squamous cell carcinoma: A single institution experience

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Lughezzani G., Catanzaro M., Torelli T., Piva L., Biasoni D., Stagni S., Crestani A., Guttilla A., Raggi D., Giannatempo P., Necchi A., Pizzocaro G., Colecchia M., Salvioni R., Nicolai N.

Journal of Urology 2014 191:4 (977-982)

Purpose We determined predictors of pelvic lymph node metastases in patients with penile cancer. Materials and Methods We retrieved a total of 188 node positive inguinal groins from 142 patients treated for penile cancer. Logistic regression models were fitted to test for predictors of pelvic lymph node metastases. The minimum p value method was used to determine the most significant cutoff values of each predictor. Results Pelvic lymph node metastases were observed in 45 cases (31.7%). The 5-year cancer specific survival rate was 71.0% vs 33.2% in patients with inguinal vs pelvic lymph node metastases. The most significant cutoff values were 3 inguinal lymph node metastases and a metastasis diameter of 30 mm. According to univariable logistic regression models the number of inguinal metastases (OR 1.92, p <0.001), the diameter of the metastases (OR 1.03, p = 0.001) and extranodal extension (OR 8.01, p <0.001) were significant predictors of pelvic lymph node metastases…(ver más)

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