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Predicting survival of patients with node-positive prostate cancer following multimodal treatment

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Abdollah F., Jeffrey Karnes R., Suardi N., Cozzarini C., Gandaglia G., Fossati N., Bianchi M., Boorjian S.A., Sun M., Karakiewicz P.I., Montorsi F., Briganti A.

European Urology 2014 65:3 (554-562)

Background According to the TNM staging system, patients with prostate cancer (PCa) with lymph node invasion (LNI) are considered a single-risk group. However, not all LNI patients share the same cancer control outcomes. Objective To develop and internally validate novel nomograms predicting cancer-specific mortality (CSM)-free rate in pN1 patients. Design, setting, and participants We evaluated 1107 patients with pN1 PCa treated with radical prostatectomy, pelvic lymph node dissection, and adjuvant therapy at two tertiary care centers between 1988 and 2010. Outcome measurements and statistical analysis Univariable and multivariable Cox regression models tested the relationship between CSM and patient clinical and pathologic characteristics, which consisted of prostate-specific antigen (PSA) value, pathologic Gleason score, pathologic tumor stage, status of surgical margins, number of positive lymph nodes, and status of adjuvant therapy. A Cox regression coefficient-based nomogram was developed and internally validated… (ver más)

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