Impact of bone and liver metastases on patients with renal cell carcinoma treated with targeted therapy

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McKay R.R., Kroeger N., Xie W., Lee J.-L., Knox J.J., Bjarnason G.A., MacKenzie M.J., Wood L., Srinivas S., Vaishampayan U.N., Rha S.-Y., Pal S.K., Donskov F., Tantravahi S.K., Rini B.I., Heng D.Y.C., Choueiri T.K.

European Urology 2014 65:3 (577-584)

Background The skeleton and liver are frequently involved sites of metastasis in patients with metastatic renal cell carcinoma (RCC). Objective To analyze outcomes based on the presence of bone metastases (BMs) and/or liver metastases (LMs) in patients with RCC treated with targeted therapy. Design, setting, and participants We conducted a review from the International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) of 2027 patients with metastatic RCC. Outcome measurements and statistical analysis. We analyzed the impact of the site of metastasis on overall survival (OS) and time-to-treatment failure. Statistical analyses were performed using multivariable Cox regression… (ver más)


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